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Discussion > Covid 19 stuff

Pharmaceutical firms don't want effective drugs, they want money-spinners.

Politicians want to score political points. Patient welfare doesn't matter.

https://wattsupwiththat.com/2020/05/11/distributed-denial-of-hcq-to-covid-19-victims/

Only 2 UK hospitals are using HCQ. Most are not trying anything, as AK has said.

Siemens, GE, Philips etc. are currently raking it in with CT scanners.

May 14, 2020 at 2:45 PM | Unregistered CommenterCharly

Covid-19 treatments in the US:

https://covid.idea.medicine.uw.edu/page/treatment/drugs

May 14, 2020 at 2:50 PM | Unregistered CommenterCharly

I see the NYT is amping up US virus casualties - I had to turn the screen to see the very light grey text that said "Opinion"


scum hardly covers it.

May 14, 2020 at 3:12 PM | Registered Commentertomo

Charly, very interesting. I wonder if you've had had any experience in reducing some of the fear factor associated with these big, shiny, space-age looking machines, machines that encase you like a womb and which commonly emit scary noises during their operations. Commonly made even scarier by needing to be injected with something beforehand and/or associated with the operators seemingly fleeing the scene.
Having had experience of most scanners now, they hold no fear for me, although I was glad to be forewarned about the noise the magnets make in a NMI Scanner. My second wife, who died of brest cancer, and was a geology lecturer like me, was petrified when confronted by one of those shiny monsters living in its own hospital cave. She freaked out, totally out of character.
I am interested because after my NMI scan I had time to talk with the operator who was worried about how to reduce patient anxiety. I told her, for patients like me the more technical information the better - atomic spinning tops and all that, but for those that the sleek, space-age appearance transported into utter fear I had no remedy. Any thoughts?

May 14, 2020 at 4:11 PM | Unregistered CommenterAK

AK

techno-fear is one of those areas that "science communicators" could usefully spend some time on - rather than recycling climate scare porn

Ignorance is a curable condition. I quite like telling people that my watch has hands filled with radioactive hydrogen that causes them to glow .... some seem a bit alarmed at that :-)

May 14, 2020 at 4:37 PM | Registered Commentertomo

AK, sorry to hear about your wife.

Magnetic resonance imagers are less claustrophic than before. If possible, you can have ear protection. Or just enjoy the unusual techo performance. For my first scan, I had the nurse hold my foot so I didn't feel I was entombed.

I can no longer go in the high-power machines - all the titanium I've been fixed with. The field induces heat. In the 90s, the NHS was still using primitive ionic contrast agents for X-ray/CT. Burning sensation, very painful.

With MRI, think carefully before accepting a gadolinium-based contrast agent. Ask which product and how much they will inject. There is evidence that some is absorbed by bone and other tissue, the chelation breaks down and you have a poisonous metal in you. Ongoing cases in US courts.

When researching the market for an ultrasound agent, the radiologists were begging for it. Product was never released.

May 14, 2020 at 5:16 PM | Unregistered CommenterCharly

Tomo. I was talking about fears that are totally unreasonable, totally beyond expectations. My wife was a highly educated woman, rational in every way except in her reaction to a scanner. I thought she was going to require sedation, but eventually I was able to calm her down. It happened more than 20 years ago but it is still scarred deeply in my memory. My friendly NMI operator told me this type of reaction is not uncommon.

May 14, 2020 at 5:24 PM | Unregistered CommenterAK

AK - aye - an old friend has two bachelor degrees and an MSc - she goes quite loopy / hysterical when there's a daddy-longlegs in the room - triggered hardly covers it -

May 14, 2020 at 5:54 PM | Registered Commentertomo

tomo, I feel sorry for daddylonglegs that come in - I try to coax them into the garden if possible - but I hate big house spiders. They get wacked.

May 14, 2020 at 6:37 PM | Unregistered CommenterCharly

Charly

I keep a plastic beer glass and a piece of card for the spiders ....

May 14, 2020 at 7:45 PM | Registered Commentertomo

Not for the squeamish - but a useful summary of Covid 19 pathology (from a lung doctor) that seems plainly missing from especially the MSM.

Answers a number of questions I hadn't thought to ask....

Being infected with coronavirus is complicated and plainly one size does not fit everybody and MDs have to pay attention to keep up...


Anyway here it is

May 17, 2020 at 9:32 AM | Registered Commentertomo

More provenance stuff

The provenance discussions have subsided quite a bit in the last several weeks

May 17, 2020 at 10:40 AM | Registered Commentertomo

RNA don’t lie.

The nickname 'Wuhan Virus' may not be correct, Chris Forster's team at Cambridge found of strain A of the virus, described as the root of the outbreak, was more common in early samples in Southern China, Guangdong province, than Wuhan - though he admits the numbers are small.

https://www.pnas.org/content/117/17/9241

May 17, 2020 at 2:13 PM | Unregistered CommenterPhil Clarke

The PNAS network analysis could usefully be mapped and calendared... but thank you Phil.

Surprisingly Wuhan CDC (not WIV) looks to be listed as having contributed a number of sequences (27?) - that facility dropped off the maps there for a while...

Unfortunately we know information from China is a lot sparser than the actual data collection.... Quite why enterprising investigative journos didn't pile in to the Weibo, WeChat, Youku resource several months ago is a bit weird, as is the radio silence from UK diplomats ( even unattributed ) - both Guangzhou and Wuhan host British Consulates and we have diplomats in HK and Taipei.

At this stage it's a useful resource but the data isn't easy to present and the percentage metric is a misleading one as anybody with half a brain and 15% banana DNA might tell you...

May 17, 2020 at 4:02 PM | Registered Commentertomo

So...

Mugabe wasn't a one-off goodwill ambassador at the WHO

May 20, 2020 at 3:35 AM | Registered Commentertomo

Large scale observational study finds no benefit from taking hydrochloroquine or chloroquine, but treatment does increase mortality.

https://eurekalert.org/pub_releases/2020-05/tl-tln052220.php

May 23, 2020 at 10:13 AM | Unregistered CommenterPhil Clarke

The quinine war rumbles on.

The direct therapeutic window of opportunity for almost *any* antiviral wrt Covid-19 is a very small one (see remdesivir) - the boosting (and in some cases the restraining) of immune response has to be the preferred primary therapeutic tactic - that and identifying those with identifiable catastrophic susceptibility to an infection beyond being old....

While the result isn't encouraging (again see remdesivir) - the efficacy as a prophylactic is I feel where the final nail might be driven in to the chloroquine venture... The anecdotal, subjective information out there about the quantity of particularly US MDs who self medicated with HCQ deserves some investigation.

100k is a good sample size of *hospitalised acute cases* - but as with almost all public health statistics there is likely more information lurking in the details. The language and presentation could do with a clean-up as being an observational study there are strong hints that there is a priori assumption that HCQ doesn't work. They could have presented it without that and let the data do the talking.

May 23, 2020 at 12:05 PM | Registered Commentertomo

May 23, 2020 at 10:13 AM Phil Clarke
Coronavirus causes death.
How is Chloroquine as a prophylactic or treatment for initial symptoms of Coronavirus if caught early?

May 23, 2020 at 12:06 PM | Unregistered Commentergolf charlie

Will the comings and goings of Cummings precipitate the going of Cummings?

Cos they bloody well should.

May 24, 2020 at 12:24 AM | Unregistered CommenterPhil Clarke

Cummings must be doing a good job as the haters hate him.

Good work Dominic. Remember "Love is Hate"

I suspect that the old style Medical Officers of Health, with the draconian powers that they held 50 years ago would be doing a better job than the Politically Correct lot we have now, on both sides of the political fences.

4th July for the restricted opening of pubs! Bring it on !

May 24, 2020 at 12:31 AM | Unregistered CommenterIantanyrallt

A Cuomo gets skewered by Kayleigh at a White House Presser that the Clarkys won't watch....

Some further info on HCQ research and ongoing investigations as to prophylaxis efficacy or lack thereof.

A doctor who'd off-label self medicated would have to be a masochist to volunteer it - unless they'd caught the virus and wanted a holiday house with a swimming pool.... There's likely some big money looking for a doctor whose attempt at prophylaxis via HCQ failed...


Clarky - that would also apply to the Imperial epidemiology shagging team then?

May 24, 2020 at 12:57 AM | Registered Commentertomo

Iantanyrallt - Cummings travelled 260 miles from London to Durham, with his partner who was exhibiting COVID-19 symptoms. At the time, the North East was one of the least affected areas and Government advice was that anyone in a household where someone has symptoms should not leave their house for 14 days. Seeing family members outside your household was specifically banned, as Matt Hancock said

“I end with the advice we all know. This advice is not a request, it is an instruction. Stay at home, protect lives and then you will be doing your part.”

The Deputy Chief Medical Officer was equally clear:-

If you are symptomatic you stay put. Take yourself out of society as quickly as you can with your family.

The Chief Medical Officer for Scotland resigned when it emerged she had travelled to her second home. SAGE member Professor Neil Ferguson went after it emerged he had breached the guidelines.

Millions have complied with the guidance at massive personal cost; people have lost loved ones with no opportunity to say goodbye or attend a funeral. These sacrifices were made willingly to save lives, and to avoid the NHS being overwhelmed.

Cummings' partner Mary Wakefield is a commissioning editor at the Spectator. That publication carried articles from both of them describing their experience with contracting the virus, but at no point did they reveal that they were sick in Durham, not London. Wakefield's piece ends:

we emerged from quarantine into the almost comical uncertainty of London lockdown

Trumpian levels of honesty, there.

In my view, the worst case outcome now is that all the good work done to get the R0 number down below 1 will be ruined as people, understandably, want to reestablish contact with loved ones and we get a seond spike. The Government advice has with some exceptions been sound, it now seems the Prime Minister's most senior advisor flaunted that advice. Lest you think this is just for lefty Guardian readers, the Telegraph just posted this…

The Telegraph understands that some friends of Mr Johnson outside No 10 had sent texts saying he had to sack Mr Cummings “for the benefit of Boris and the country”.

The friend – who claimed he was appalled that Mr Cummings was not more contrite yesterday – said: “This is a car crash. I feel sad for the two of them but the truth is it was the wrong thing to do.“It is not about Dominic, it is about perception. And when lives matter you may never recover from this.“

If this turns out to be that he stays, there is a public backlash and people say ‘I am going to sit in the park’, and the R rate goes to 1.5 and people start to die again, it could be finished.”An MP ally of Mr Johnson said Mr Cummings should quit, but probably would not.

.The MP said the problem was that the people around the Prime Minister felt that they were above the law.The Conservative MP said: “It is very damaging for the Government because it builds on this belief that there is a genuine feeling in Number 10 that they are above the law.”

Cummings goes or more people die. Clear?

May 24, 2020 at 1:32 AM | Unregistered CommenterPhil Clarke

my brother is correct - hanging would be too good for Cummings - he should be crushed to death under a pile of unsold newspapers.

May 24, 2020 at 3:44 AM | Unregistered CommenterKaren Clarke

May 24, 2020 at 1:32 AM Phil Clarke
May 24, 2020 at 3:44 AM Karen Clarke

Are either of you connected to Gary Evans of Greenpeace and The Guardian aka Bluecloud? He wanted to kill people too.

May 24, 2020 at 9:00 AM | Unregistered Commentergolf charlie

CGTN: Since the outbreak began, there has been speculation that the novel coronavirus leaked from the Wuhan Institute of Virology. How do you respond to that?

Wang: This is pure fabrication. Our institute first received the clinical sample of the unknown pneumonia on December 30 last year. After we checked the pathogen within the sample, we found it contained a new coronavirus, which is now called SARS-CoV-2. We didn't have any knowledge before that, nor had we ever encountered, researched or kept the virus. In fact, like everyone else, we didn't even know the virus existed. How could it have leaked from our lab when we never had it?

https://news.cgtn.com/news/2020-05-23/Exclusive-with-head-of-Wuhan-Institute-of-Virology-Let-science-speak-QJeOjOZt4Y/index.html

Sorry, conspiracy fans.

May 24, 2020 at 11:39 AM | Unregistered CommenterPhil Clarke